Researchers at The City College of New York have linked chemotherapy treatment to lasting cognitive changes in rats – potentially shading light, for the first time, on cognitive problems some cancer survivors experience long after treatment ends. Entitled “Chemotherapy treatment alters DNA methylation patterns in the prefrontal cortex of female rat brain,” the study appears in the journal Nature: Scientific Reports.
Our study explored how chemotherapy affects the brain at the molecular level using an animal model. We found that chemotherapy doesn’t just target cancer cells – it also disrupts how genes are regulated in the brain, specifically in the prefrontal cortex, the area responsible for decision-making and executive…
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