Aging-related diseases, including cancer, cardiovascular disorders and type 2 diabetes, are associated with defects in protein synthesis and folding.
Previous studies have shown that protein misfolding occurs in insulin-producing β-cells of patients with type 2 diabetes. These cells are found in pancreatic islets.
The resulting stress was believed to mainly occur within the endoplasmic reticulum, which is responsible for producing and distributing proteins to the cell.
Ultimately, the stress results in cell death.
In a study published in Nature Metabolism, researchers at the University of Michigan found that mitochondria also accumulate misfolded proteins, which kills β-cells.
Reversing this process could help treat type 2…
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