A new article in the peer-reviewed journal Nucleic Acid Therapeutics describes the characterization of antibodies targeting antisense oligonucleotide (ASO) phosphorothioate and 2′-methoxyehtyl modifications for intracellular trafficking and biodistribution studies.
Peter Oliver and Xiao Wan, from the Research Complex at Harwell, U.K., and coauthors, validated new panels of antibody reagents that target clinically relevant nucleic acid modifications for visualizing ASOs both in vitro and in vivo. The investigators tested ASOs in vitro for intracellular localization by immunocytochemistry and for biodistribution in mouse tissues by immunohistochemistry.
“Our data demonstrate the utility of these reagents for the NAT field,…
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