UCSF discovery points to new strategies for Alzheimer’s treatment

1753697827 Alzheimers amyloid plaque Juan Gaertner 9638f1223d534b518a192c8478871d65



Alzheimers amyloid plaque Juan Gaertner 9638f1223d534b518a192c8478871d65

UCSF scientists have discovered how microglia engulf and break down amyloid beta, a protein that builds up in Alzheimer’s, with devastating consequences for the brain. 

In Alzheimer’s disease, proteins like amyloid beta form clumps, known as plaques, that damage the brain. 

But in some people, immune cells called microglia break down these proteins before they can cause harm. This leads to fewer and smaller clumps – and much milder symptoms.

Researchers at UC San Francisco identified a molecular receptor that enables microglia to gobble up and digest amyloid beta plaques. 

Without the receptor, ADGRG1, the microglia barely nibbled on the toxic protein. Using a mouse model of Alzheimer’s disease, the researchers observed how…



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