A team led by UT Southwestern Medical Center researchers has uncovered the atomic structure of a protein complex pivotal to the function of motile cilia, the hair-like structures extending from the surfaces of many cell types that generate their movement.
The researchers’ findings involving radial spoke 3 (RS3), reported in Nature Structural & Molecular Biology, help answer some fundamental questions about how motile cilia work and could eventually lead to new treatments for ciliopathies, diseases in which cilia’s structure and/or function are impaired. These include primary ciliary dyskinesia, a life-shortening genetic disorder that causes infertility, chronic respiratory problems, reversed organ placement, and excess brain…
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