New approach doubles chemotherapy effectiveness by targeting cancer cell memory

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In a wholly new approach to cancer treatment, Northwestern University biomedical engineers have doubled the effectiveness of chemotherapy in animal experiments.

Instead of attacking cancer directly, the first-of-its-kind strategy prevents cancer cells from evolving to withstand treatment – making the disease easier to target with existing drugs. Not only did the approach fully wipe out the disease to near completion in cellular cultures, but it also dramatically increased the effectiveness of chemotherapy in mouse models of human ovarian cancer.

The study was published today (July 22) in the Proceedings of the National Academy of Sciences.

“Cancer cells are great adapters,” said Northwestern’s Vadim Backman, who led the study….



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