Outsmarting insecticide resistance: How one genetic edit in mosquitoes self-propagates across generations, cutting malaria transmission to near zero without harming survival.
Anopheles mosquito larva – Study: Driving a protective allele of the mosquito FREP1 gene to combat malaria. Image Credit: Sinhyu Photographer / Shutterstock
In a recent study published in the journal Nature, a group of researchers investigated whether the fibrinogen-related protein 1 (FREP1) glutamine 224 (Q224) allele renders Anopheles stephensi mosquitoes refractory to Plasmodium infection, quantified the fitness costs associated with this allele, and evaluated a linked allelic drive system to spread this protective variant through…
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