Experimental drug found to be safe and effective in treating children with MIS-C

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In a small trial, Mass General Brigham researchers found a drug designed to treat Celiac disease supported a more rapid return to normal activities for patients following COVID.

Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious condition that can occur after a COVID-19 infection, presenting as high fevers, gastrointestinal symptoms, and life-threatening cardiac injury. A small, randomized clinical trial led by Mass General Brigham investigators found the oral drug larazotide-an experimental drug originally designed to treat Celiac disease-was both safe and effective in treating children with MIS-C. Their results are published in Science Translational Medicine.

While our study is small, its results are…



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