A new study led by Stephen D. Nimer, M.D., director of Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, shows how a key molecule regulates the generation of new blood cells, a process called hematopoiesis that goes awry in cancer. The findings have the potential to lead to new therapeutic strategies targeting the molecule, a regulator of gene activity called TAF1.
The new findings “not only challenge prevailing models of hematopoietic regulation but also lay the groundwork for innovative clinical applications,” said Sylvester researcher Ramin Shiekhattar, Ph.D., co-leader of the Cancer Epigenetics Program at Sylvester and chief of the Division of Cancer Genomics and Epigenetics. He…
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